The United States Medical Licensing Examination® (USMLE®) is a three-step examination for medical licensure in the United States. The USMLE is designed for students of allopathic medicine, who are on the path to an MD. Students of osteopathic medicine can take either the USMLE or a similar test called the Comprehensive Osteopathic Medical Licensing Examination (COMEX). The USMLE Step 1 is a one-day computer exam taken by most medical students at the end of their second year of medical school. It is also taken by thousands of international medical graduates (IMGs). The USMLE Step 1 emphasizes basic science principles, specifically anatomy, behavioral science, biochemistry, microbiology, pathology, pharmacology, and physiology. Interdisciplinary areas such as genetics, immunology, and nutrition are also tested.